Methyl 4, 6-dichloro-3-(diethylamino) furo [3, 4-c] pyridine-1-carboxylate (6), an intermediate in the Hamaguchi-Ibata reaction involving the RhII-catalyzed intramolecular reaction of a diazo group with the carbonyl of an adjacent amido group, has been isolated and characterized. PM3 calculations reveal the heat of formation (Δ H f) of this remarkably stable molecule to be-77.7 kcal/mol. Compound 6 undergoes a facile Diels-Alder cycloaddition ...
