Highly functionalised sulfur-based silica scavengers for the efficient removal of palladium species from active pharmaceutical ingredients

N Galaffu, SP Man, RD Wilkes…

Index: Galaffu, Nicola; Man, Siud Pui; Wilkes, Robin D.; Wilson, John R. H. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 406 - 413

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Citation Number: 47

Abstract

The use of multidentate sulfur-based silica scavengers 1, 2, and 3 as highly effective adsorbents for the removal of precious metals, specifically palladium residues in this paper, from highly functionalised synthetic intermediates and APIs is described. The synthesis and purification of the polar and electron-rich reaction products, containing multiple functional groups, from palladium-catalysed removals of commonly used protecting groups such as ...