1, 2, 4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities

GEDAA Abuo-Rahma, M Abdel-Aziz, EAM Beshr…

Index: Abuo-Rahma, Gamal El-Din A.A.; Abdel-Aziz, Mohamed; Beshr, Eman A.M.; Ali, Taha F.S. European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 185 - 198

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Citation Number: 15

Abstract

Abstract A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity and antiproliferative activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited ...