Abstract All the stereoisomers of stenusine (1) and norstenusine (21) have been efficiently synthesized by the asymmetric hydrogenation of pyridines. The (2R, 3S)-and (2R, 3R)- isomers of 1, that are difficult to prepare, have been synthesized for the first time using a chemoenzymatic approach in eight steps with an 8% total yield. All the target compounds were obtained in good stereochemical purity by using very simple and inexpensive ...
