New 2-pyridylethylamines with dopaminergic activity: Synthesis and radioligand-binding evaluation

…, G Giorgioni, M Cardellini, F Amenta, C Polidori

Index: Claudi; Cingolani; Giorgioni; Cardellini; Amenta; Polidori European Journal of Medicinal Chemistry, 1995 , vol. 30, # 5 p. 415 - 421

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Citation Number: 12

Abstract

In order to determine whether the pyridine nucleus could replace the catechol moiety of the neurotransmitter dopamine or the phenol ring of the dopaminergic pharmacophore m- hydroxyphenylethylamine, the 2-(3-pyridyl) ethylamine 7, 2-(4-pyridyl) ethylamine 8, 2-(2- hydroxy-4-pyridyl) ethylamine 10 and their N, N-di-n-propyl and Nn-propyl-N-2-phenylethyl derivatives were synthesized. The affinities of the new compounds for D1 and D2 ...