Dibenzazepine derivatives have represented and still represent today an interesting and exciting field of investigation in medicinal chemistry. l-16 A slight modification of the tricyclic structure leads to a profound alteration of the activity profile. Indeed, clothiapine (1) is a typicalne~ roleptic'~ with a strong propensity to induce extrapyramidal symptoms (EPS), while clozapine (2) and fluperlapine (3) show an atypical antipsychotic profilela21 and ...
