e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Biologically useful chelators that release Ca2+ upon illumination
SR Adams, JPY Kao, G Grynkiewicz…
Index: Adams, S. R.; Kao, J. P. Y.; Grynkiewicz, G.; Minta, A.; Tsien, R. Y. Journal of the American Chemical Society, 1988 , vol. 110, # 10 p. 3212 - 3220
Abstract: A series of Ca2+-selective chelators incorporating a photosensitive o- nitrobenzhydryl ether, alcohol, or ester (A,,, 350-360 nm, c 4500 MI cm-l) were synthesized. The key step of the syntheses required the novel and mild trimethylsilyl triflate catalyzed Friedel-Crafts alkylation of a N, N-dialkylaniline by a nitrobenzaldehyde or its acetal. Before photolysis, the chelators show dissociation constants for Ca2+ of about lo-'M, roughly ...
![diethyl 2,2'-((2-(2-(2-(bis(2-ethoxy-2-oxoethyl)amino)-5-(methoxy(6-nitrobenzo[d][1,3]dioxol-5-yl)methyl)phenoxy)ethoxy)-4-methylphenyl)azanediyl)diacetate Structure](https://image.chemsrc.com/caspic/201/103471-63-2.png)
![2-[2-[2-[2-[bis(carboxymethyl)amino]-5-[methoxy-(6-nitro-1,3-benzodioxol-5-yl)methyl]phenoxy]ethoxy]-N-(carboxymethyl)-4-methylanilino]acetic acid Structure](https://image.chemsrc.com/caspic/163/103471-64-3.png)