Adenosine derivatives bearing an W-(3-iodobenzyl) group, reported to enhance the afinity of adenosine-5'-uronamide analogues as agonists at A3 adenosine receptors (J. Med. Chem. 1994, 37, 636-646), were synthesized starting from methyl PD-ribofuranoside in 10 steps. Binding affinities at A1 and Aza receptors in rat brain membranes and at cloned rat & receptors from stably transfected CHO cells were compared. W-(3-Iodobenzyl) adenosine ...
