Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids

K Hioki, Y Takechi, N Kimura, H Tanaka…

Index: Hioki, Kazuhito; Takechi, Yumiko; Kimura, Noriyo; Tanaka, Hiroyuki; Kunishima, Munetaka Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 12 p. 1735 - 1737

Full Text: HTML

Citation Number: 5

Abstract

Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4, 6- dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.