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A Catalytic Approach to the Synthesis of (+)??Fluvastatin Analogue.

A Kim, IS Kim

Index: Kim, Aejin; Kim, In Su Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 10 p. 3748 - 3751

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Citation Number: 7

Abstract

Statins are a class of drugs that lower the cholesterol level in the blood by blocking hydroxy- methylglutaryl-coenzyme A reductase (HMG-CoA reductase) in the liver (Figure 1). Statins have become the most frequently prescribed agent for the treatment of hypercholesterolemia due to their effect on reducing the rates of cardiovascular events. 1 Fluvastatin (Lescol TM) inhibits the enzyme that reduces 3-hydroxy-3-methylglutaric acid to mevalonic acid, thus ...