5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials

…, DS Pedersen, R Morona, L Zhang, GW Booker…

Index: Zvarec, Ondrej; Polyak, Steven W.; Tieu, William; Kuan, Kevin; Dai, Huanqin; Pedersen, Daniel Sejer; Morona, Renato; Zhang, Lixin; Booker, Grant W.; Abell, Andrew D. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2720 - 2722

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Citation Number: 22

Abstract

Herein we outline the antibacterial activity of amino acid containing thiazolidinediones and rhodanines against Gram-positive bacteria Staphylococcus aureus ATCC 31890, Staphylococcus epidermidis and Bacillus subtilis ATCC 6633. The rhodanine derivatives were generally more active than the analogous thiazolidinediones. Compounds of series 5 showed some selectivity for Bacillus subtilis ATCC 6633, the extent of which is enhanced ...