Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di-and Tri-Substituted 1, 3, 5-Triazines

…, U Pratap Singh, H Raj Bhat, P Gahtori

Index: Ghosh, Surajit Kumar; Saha, Ashmita; Hazarika, Bornali; Singh, Udaya Pratap; Bhat, Hans Raj; Gahtori, Prashant Letters in Drug Design and Discovery, 2012 , vol. 9, # 3 p. 329 - 335

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Abstract

Due to overwhelming generation of drug resistant microorganisms, there is an urgent need to develop novel chemotherapeutic agents. In continuation of our research on discovery of novel heterocyclic scaffolds from 1, 3, 5-triazine, present study deals with design and development of some novel di-and tri-substituted 1, 3, 5-triazine derivatives. The synthesis of title analogues were accomplished by SNAr reaction and subsequently underwent ...