Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection

KN Venugopala, RT Prasanna…

Index: Venugopala, K. Narayanaswamy; Prasanna, Renuka T.; Odhav, Bharti Asian Journal of Chemistry, 2013 , vol. 25, # 15 p. 8685 - 8689

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Abstract

Abstract In the present work, we demonstrated a simple and an efficient method for the condensation of substituted aryl/heteroaryl amines with acetonylacetone in the presence of trifluoro acetic acid to afford the corresponding 2, 5-dimethyl-1-substitued pyrroles using Paal-Knorr synthesis in excellent yields. Trifluoroacetic acid was used under reflux condition for the deprotection of 2, 5-dimethyl-1-substitued pyrroles to their corresponding ...