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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Helvetica chimica acta

Pteridines, part CXIII

Q Yao, W Pfleiderer

Index: Yao, Qizheng; Pfleiderer, Wolfgang Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 1 - 12

Full Text: HTML

Citation Number: 16

Abstract

Abstract The low solubility of pterins can drastically be improved by N 2-acylation or formation of the N 2-[(dimethylamino) methylene] derivatives. Both types of compounds can be alkylated under Mitsunobu conditions to form from N 2-acylpterins (see 2 and 3) and their

 Related Synthetic Route
N-{[(acetyloxy)methyl]-4-[2-(4-nitrophenyl)ethoxy]pteridin-2-yl}acetamide Structure

522614-11-5

N-{[(acetyloxy)...

~53%

2,4-diamino-6-(hydroxymethyl)pteridine Structure

945-24-4

2,4-diamino-6-(...

N-{4-[2-(4-nitrophenyl)ethoxy]pteridin-2-yl}acetamide Structure

522614-07-9

N-{4-[2-(4-nitr...

~54%

2,4-Pteridinediamine Structure

1127-93-1

2,4-Pteridinediamine

N2-acetylpterin Structure

13165-97-4

N2-acetylpterin

~%

2,4-Pteridinediamine Structure

1127-93-1

2,4-Pteridinediamine

4-[2-(4-nitrophenyl)ethoxy]pteridin-2-amine Structure

522614-23-9

4-[2-(4-nitroph...

~%

2,4-Pteridinediamine Structure

1127-93-1

2,4-Pteridinediamine

2-{[(dimethylamino)methylene]amino}pteridin-4(3H)-one Structure

445033-65-8

2-{[(dimethylam...

~51%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

2-{[(dimethylamino)methylene]amino}pteridin-4(3H)-one Structure

445033-61-4

2-{[(dimethylam...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one Structure

522614-27-3

2-{[(dimethylam...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

2-Amino-1,5-dihydropteridin-4-ol Structure

2236-60-4

2-Amino-1,5-dih...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

N2-acetylpterin Structure

13165-97-4

N2-acetylpterin

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

2-amino-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one Structure

522614-33-1

2-amino-3-[2-(4...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

4-[2-(4-nitrophenyl)ethoxy]pteridin-2-amine Structure

522614-23-9

4-[2-(4-nitroph...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

N-{4-[2-(4-nitrophenyl)ethoxy]pteridin-2-yl}acetamide Structure

522614-07-9

N-{4-[2-(4-nitr...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

N-{3,4-dihydro-3-[2-(4-nitrophenyl)ethyl]-4-oxopteridin-2-yl}acetamide Structure

522614-36-4

N-{3,4-dihydro-...

~%

2-imino-3-methyl-4aH-pteridin-4-one Structure

941-90-2

2-imino-3-methy...

N-{4-[2-(4-nitrophenyl)ethoxy]-6,7-diphenylpteridin-2-yl}acetamide Structure

522614-16-0

N-{4-[2-(4-nitr...

~58%

2,4-Pteridinediamine,6,7-diphenyl- Structure

18181-93-6

2,4-Pteridinedi...

4(3H)-Pteridinone,2-amino-6,7-diphenyl- Structure

17376-91-9

4(3H)-Pteridino...

~%

2,4-Pteridinediamine,6,7-diphenyl- Structure

18181-93-6

2,4-Pteridinedi...

N/A Structure

522614-06-8

N/A

~%

2,4-Pteridinediamine,6,7-diphenyl- Structure

18181-93-6

2,4-Pteridinedi...

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Detail Synthetic Route


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