. alpha.-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model

S Thaisrivongs, DT Pals, JA Lawson…

Index: Thaisrivongs; Pals; Lawson; Turner; Harris Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 536 - 541

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Citation Number: 43

Abstract

We have initiated a program with the intention of overcoming the problem of short biological half-life of these peptides, and in our previous reports, 1 we described our work on peptide backbone modification that led to the demonstration of an orally active renin inhibitory peptide. The present study reports a variant of this approach that has resulted in enzyme inhibitors with comparable biological half-life. It is our conviction that a focus on in vivo ...