Model systems for flavoenzyme activity: intramolecular self-assembly of a flavin derivative via hydrogen bonding and aromatic interactions

…, G Cooke, SG Hewage, S Mabruk, G Rabani…

Index: Caldwell, Stuart T.; Cooke, Graeme; Hewage, Shanika G.; Mabruk, Suhil; Rabani, Gouher; Rotello, Vincent; Smith, Brian O.; Subramani, Chandramouleeswaran; Woisel, Patrice Chemical Communications, 2008 , # 35 p. 4126 - 4128

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Citation Number: 10

Abstract

In our continuing studies to develop model systems for flavoenzymes, and in particular mimics for flavoenzymes where the cofactor is covalently bound to the apoenzyme, we wanted to develop a model system to study the combined effects of intramolecular aromatic 5 and hydrogen bonding interactions have on the physical properties of the flavin unit. Compound 1 was designed to allow us to explore these dual effects as the diamidopyridine moiety (DAP) is known to form ...