There were a number of issues associated with this synthesis which precluded its use as the long-term route of manufacture. Use of p-iodophenol generates iodine-containing waste streams and associated high disposal costs. The use of a BOC protecting group for the piperidone raises issues of thermal stability and the generation of isobutylene as a byproduct. The cryogenic temperature and low yield for the Grignard reaction was unsatisfactory and the resulting ...
[Cramer, Jacob R.; Ning, Yanxiao; Shen, Cai; Nuermaimaiti, Ajiguli; Besenbacher, Flemming; Linderoth, Trolle R.; Gothelf, Kurt V. European Journal of Organic Chemistry, 2013 , # 14 p. 2813 - 2822]
