Lipase-catalyzed synthesis of carboxylic amides: nitrogen nucleophiles as acyl acceptor

F van Rantwijk, MAPJ Hacking, RA Sheldon

Index: Van Rantwijk, Fred; Hacking, Michiel A.P.J.; Sheldon, Roger A. Monatshefte fur Chemie, 2000 , vol. 131, # 6 p. 549 - 569

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Citation Number: 72

Abstract

Summary. The lipase-catalyzed aminolysis of carboxylic esters is a fairly general reaction that has been performed with a wide range of esters and amines, generally in anhydrous organic media to avoid undesirable hydrolysis of the ester. Alternatively, carboxylic amides can be synthesized by lipase mediated condensation of carboxylic acids and amines if an excess of either reactant is avoided. Chiral carboxylic esters have been resolved by lipase ...