The Journal of Organic Chemistry

An electrophile-assisted nonsolvent synthesis of alkyl macroisocyclic ethers: an improved nonsolvent Williamson synthesis of medium-sized alkyl carbocyclic ethers

JJ Chapman, JR Reid

Index: Chapman, John J.; Reid, Jack R. Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3757 - 3759

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Citation Number: 3

Abstract

(9) Still, WC; Kahn, M.; Mitra, AJ Org. Chem. 1978, 43, 2923.(10) A typical procedure as follows: A flame-dried two-neck roundbottom flask equipped with a stirring bar and a rubber septum under nitrogen atmosphere was charged with 156 mg (1 mmol, specific activity= 6 mCi/mmol) of [l'C] methyl phenyl sulfone in 5 mL of dry THF. The reaction flask was cooled to 0 OC, and 0.80 mL (2.0 mmol) of n-butyllithium in hexane was added to yield a fine yellow ...