Cyclobutanedicarboxylic acids. VIII. Synthesis and curariform activity of bisquaternary salts of α-truxillic acid ω-dialkylaminoalkylamides

…, NA Abramova, AP Skoldinov, DA Kharkevich

Index: Arendaruk, A. P.; Abramova, N. A.; Skoldinov, A. P.; Kharkevich, D. A. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 464 - 467 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 802 - 806

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Abstract

It has previously been shown [i, 3] that bisquaternary salts of~-dialkylaminoalkyl 1, 3- diphenylcyclobutane-2, 4-dicarboxylates have pronounced curariform activity. From a large number of compounds of this type synthesized and examined, two of the most active, cyclobutonium (I) and anatruxonium (II)[4] were selected, and after extensive pharmacological and clinical studies these were accepted by the Pharmacological ...