A facile approach to substituted acrylates by regioselective and stereoselective addition of thiols and amines to an alkynyl ester in water

NA Randive, V Kumar, VA Nair

Index: Randive, Nitin A.; Kumar, Varun; Nair, Vipin A. Monatshefte fur Chemie, 2010 , vol. 141, # 12 p. 1329 - 1332

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Citation Number: 8

Abstract

Abstract Water-promoted hydrothiolation and hydroamination of ethyl propiolate leading to highly regioselective and stereoselective formation of thioacrylates and β-enamino esters in excellent yields, by a simple, efficient, and environmentally friendly reaction procedure without employing any hazardous reagent or solvent is reported. Graphical Abstract

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Discovery of potent and selective pyrazolopyrimidine janus k...

[Hanan, Emily J.; Van Abbema, Anne; Barrett, Kathy; Blair, Wade S.; Blaney, Jeff; Chang, Christine; Eigenbrot, Charles; Flynn, Sean; Gibbons, Paul; Hurley, Christopher A.; Kenny, Jane R.; Kulagowski, Janusz; Lee, Leslie; Magnuson, Steven R.; Morris, Claire; Murray, Jeremy; Pastor, Richard M.; Rawson, Tom; Siu, Michael; Ultsch, Mark; Zhou, Aihe; Sampath, Deepak; Lyssikatos, Joseph P. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10090 - 10107]