A, EtOAc; B, EtOAc/i-Pr, O; C, MeCN; D, EtOAc/Et, O; E, i-PrOH/EtOAc/MeCN (1: 2: 4); F, blockers not only did not abolish the 0-adrenoceptor action but led in some cases to potent selective P2 antagonists. 2b It seemed, therefore, that the distance between the aromatic nucleus and the N atom could be modified, and this point led us to reconsider the role and the importance of the aromatic nucleus itself. To the best of our knowledge, such an ...
