A new, convenient and high yielding procedure for the preparation of bis (indolyl) methanes in water by electrophilic substitution reaction of indoles with different carbonyl compounds in the presence of a catalytic amount of [Cu (3, 4-tmtppa)](MeSO4) 4 (1mol%) as a highly stable and reusable catalyst is described. This procedure has also been applied successfully for the preparation of bis (pyrazole-5-ols) and dipyrromethanes.
![2-[(4-bromophenyl)-(1H-pyrrol-2-yl)methyl]-1H-pyrrole Structure](https://image.chemsrc.com/caspic/284/159152-11-1.png)
![4-[(4-chlorophenyl)-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methyl]-5-methyl-2-phenyl-1H-pyrazol-3-one Structure](https://image.chemsrc.com/caspic/263/143699-06-3.png)