Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release

…, J Chen, L Kuznetsova, SS Wong, I Ojima

Index: Chen, Shuyi; Zhao, Xianrui; Chen, Jingyi; Chen, Jin; Kuznetsova, Larisa; Wong, Stanislaus S.; Ojima, Iwao Bioconjugate Chemistry, 2010 , vol. 21, # 5 p. 979 - 987

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Citation Number: 116

Abstract

An efficient mechanism-based tumor-targeting drug delivery system, based on tumor- specific vitamin-receptor mediated endocytosis, has been developed. The tumor-targeting drug delivery system is a conjugate of a tumor-targeting molecule (biotin: vitamin H or vitamin B-7), a mechanism-based self-immolative linker and a second-generation taxoid (SB- T-1214) as the cytotoxic agent. This conjugate (1) is designed to be (i) specific to the ...