N-(2, 3-Butadienyl)-1, 4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase

…, FN Bolkenius, N Seiler, P Casara

Index: Bey, Philippe; Bolkenius, Frank N.; Seiler, Nikolaus; Casara, Patrick Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 1 - 2

Full Text: HTML

Citation Number: 135

Abstract

2--I-3 (a) N, N'-Dicyclohexylcarbodiimide, HO, C (CH,), NHBOC, CH, CN;(b)(i-Pr), NH, CuBr, HCHO in dioxane, reflux, 1 h;"(c) LiAlH, in Et, O, room temperature, 2 days;(d) HC1 gas in Et, O;(e)(t-BuOCO), O;(f) NaH in DMF, 1, 4-diiodobutane, 3 h, room temperature;(9) NaH in THF, CH, I;(h) BH, in THF, 20 h, room temperature;(i) mesyl chloride, NEt,,-10" C in CH, Cl,, then MgI, in Et, O;(j) NaH in DMF, 0'C, 2 h.