Molecules

2-(3, 4-dihydro-4-oxothieno [2, 3-d] pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation

…, T Chen, J Liu, R Ma, W Lu, J Huang, H Li, J Li, H Jiang

Index: Zhu, Jin; Chen, Tong; Liu, Jie; Ruoqun, Ma.; Lu, Weiqiang; Huang, Jin; Li, Honglin; Li, Jian; Jiang, Hualiang Molecules, 2009 , vol. 14, # 2 p. 785 - 797

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Citation Number: 9

Abstract

Abstract: The cysteine protease falcipain-2 (FP-2) of Plasmodium falciparum is a principal cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites, making it become an attractive target enzyme for developing anti-malarial drugs. In this study, a series of novel small molecule FP-2 inhibitors have been designed and synthesized based on compound 1, which was identified by using structure-based ...