Abstract The concise and practical synthesis of the biologically important FTY720 was achieved employing the palladium-catalyzed Sonogashira coupling reaction as a key step. The commercial tris (hydroxymethyl) aminomethane was converted to alkyne 2 via a three- step synthesis. The coupling reactions of alkyne 2 with aryl iodide 3, followed by subsequent hydrogenation of the internal alkyne and removal of the protecting groups provided ...
![N-[2,2-Dimethyl-5-[2-(4-octylphenyl)ethyl]-1,3-dioxan-5-yl]carbamic acid 1,1-dimethylethyl ester Structure](https://image.chemsrc.com/caspic/224/885605-36-7.png)
