. alpha.-Helical versus 310-Helical Conformation of Alanine-Based Peptides in Aqueous Solution: An Electron Spin Resonance Investigation

…, CR Nakaie, GR Marshall

Index: Smythe, Mark L.; Nakaie, Clovis R.; Marshall, Garland R. Journal of the American Chemical Society, 1995 , vol. 117, # 42 p. 10555 - 10562

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Citation Number: 89

Abstract

Abstract: Due to the difficulties in experimentally differentiating between the a-and 3 10- helical conformations in solution, isolated helical peptides have been assumed to be in the a- helical conformation. However, recent electron spin resonance (ESR) studies have suggested that such peptides, in particular short alanine-based peptides, are 310-helical (Miick, SM; et al. Nature 1992, 359, 653-5). This result prompted us to further investigate ...