Immobilized heterologous Rhizopus oryzae lipase as an efficient catalyst in the acetylation of cortexolone

PG Quintana, M Guillén, M Marciello…

Index: Quintana, Paula G.; Guillen, Marina; Marciello, Marzia; Valero, Francisco; Palomo, Jose M.; Baldessari, Alicia European Journal of Organic Chemistry, 2012 , # 23 p. 4306 - 4312

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Citation Number: 13

Abstract

Abstract The enzymatic preparation of a monoacetyl derivative of the corticosteroid cortexolone, through a transesterification reaction, is described. The heterologous Rhizopus oryzae lipase, immobilized on three different supports, proved to be an efficient catalyst in the acylation reaction using a complex substrate such as cortexolone. Immobilization of the enzyme on Lewatit 1600 resin at pH= 7 and 25 C was the best condition for catalysis of ...