Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

…, S Klutchko, T Winters, EE Reynolds, KM Welch…

Index: Cheng; Lee; Klutchko; Winters; Reynolds; Welch; Flynn; Doherty Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 24 p. 2999 - 3002

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Citation Number: 17

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Screening of a compound library against endothelin receptors (ET A and ET B ) revealed PD 102566 (compound 1) as an ET A selective antagonist. Synthesis and structure-activity relationships (SAR) of a series of analogs are described. ... Screening of a compound library against ...