Chinese Journal of Catalysis

Silica sulfuric acid: An efficient heterogeneous catalyst for the one-pot synthesis of 1, 4-dihydropyridines under mild and solvent-free conditions

B Datta, MA Pasha

Index: Datta, Bandita; Pasha, M. Afzal Chinese Journal of Catalysis, 2011 , vol. 32, # 6-8 p. 1180 - 1184

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Citation Number: 16

Abstract

A series of 1, 4-dihydropyridines have been prepared by a one-pot condensation of aldehydes, ethyl acetoacetate, and ammonium acetate in the presence of a heterogeneous catalyst silica sulfuric acid at room temperature under solvent-free condition. This new protocol has the advantage of short reaction time and excellent yields, and is an environmentally benign route to the synthesis of 1, 4-dihydropyridines.