N-Methoxy-N-methyl amides (Weinreb amides) are very useful intermediates in organic synthesis since they react efficiently with organometallics and hydrides to produce the ketones and the aldehydes, respectively, l The N-methoxy-N-methyl amides have been generally prepared by condensation of carboxylic acids and N, O-dimethylhydroxylamine hydrochloride in the presence of a coupling reagent such as DEPC or py.BOP, or by treatment of lactones, esters or ...
