Development of 3, 4-dihydroisoquinolin-1 (2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ 2 receptors

…, R Perrone, F Berardi, M Niso, SM Ametamey

Index: Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M. European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 920 - 930

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Citation Number: 16

Abstract

Abstract σ 2 Receptors are promising biomarkers for cancer diagnosis given the relationship between the proliferative status of tumors and their density. With the aim of contributing to the research of σ 2 receptor Positron Emission Tomography (PET) probes, we developed 2- [3-[6, 7-dimethoxy-3, 4-dihydroisoquinolin-2 (1H)-yl] propyl]-3, 4-dihydroisoquinolin-1 (2H)- one (3), with optimal σ 2 pharmacological properties and appropriate lipophilicity. Hence, ...