Organic letters

Synthesis of 2-C-methyl-D-erythritol 4-phosphate: The first pathway-specific intermediate in the methylerythritol phosphate route to isoprenoids

AT Koppisch, BSJ Blagg, CD Poulter

Index: Koppisch, Andrew T.; Blagg, Brian S. J.; Poulter, C. Dale Organic Letters, 2000 , vol. 2, # 2 p. 215 - 217

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Citation Number: 40

Abstract

2-C-Methyl-d-erythritol 4-phosphate (4), formed from 1-deoxy-d-xylulose 5-phosphate (3), is the first pathway-specific intermediate in the methylerythritol phosphate route for the biosynthesis of isoprenoid compounds in bacteria, algae, and plant chloroplasts. In this report, 4 was synthesized from 1, 2-propanediol (7) in seven steps with an overall yield of 32% and in an enantiomeric excess of 78%.