Practical method for transforming alkynes into α-diketones

…, CD Jones, D Mitchell, JY Pu, TY Zhang

Index: Wan, Zhonghui; Jones, Chauncey D.; Mitchell, David; Pu, John Y.; Zhang, Tony Y. Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 826 - 828

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Citation Number: 78

Abstract

Oxidation of alkynes to α-dicarbonyl derivatives through a convenient one-pot procedure via a Brønsted acid-promoted “hydration” and a DMSO-based oxidation sequence has been achieved in high yields. The scope and limitations of the reaction have also been investigated.

~66%

~49%

~76%

Antiinflammatory 4, 5-diarylimidazoles as selective cyclooxy...

[Barta, Thomas E.; Stealey, Michael A.; Collins, Paul W.; Weier, Richard M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3443 - 3448]

Synthesis and biological evaluation of 2, 3-diarylpyrazines ...

[Singh, Sunil K.; Saibaba; Ravikumar; Rudrawar, Santosh V.; Daga, Pankaj; Rao, C. Seshagiri; Akhila; Hegde; Rao, Y. Koteswar Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1881 - 1893]

The Absorption Spectra of Tetracyclones. IV1, 2

[Coan et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 60,62, 63]