Tetrahedron letters

A short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric α-aminooxylation

SP Kotkar, A Sudalai

Index: Kotkar, Shriram P.; Sudalai, Arumugam Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6813 - 6815

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Citation Number: 43

Abstract

The literature methods for the synthesis of levetiracetam typically involve chiral pool approaches starting from enantiopure α-amino acids, 3 resolution of Etiracetam or advanced racemic intermediates, 3a and 4 asymmetric hydrogenation over Rh(I) or Ru(II) complexes, 5 and deracemization of 2-bromobutyric acid using N-phenylpantolactam as a chiral auxiliary. 6 As a part of our research program aimed at developing stereocontrolled syntheses of bioactive molecules, 7 we ...