Abstract The high enantioselective rhodium-catalyzed hydroformylation of 1, 1-disubstituted allylphthalimides has been developed. By employing chiral ligand 1, 2-bis [(2S, 5S)-2, 5- diphenylphospholano] ethane [(S, S)-Ph-BPE], a series of β 3-aminoaldehydes can be prepared with up to 95% enantioselectivity. This asymmetric procedure provides an efficient alternative route to prepare chiral β 3-amino acids and alcohols.
