The proposed formation of 3-hydroxy-4, 5-dimethyl-2 (5 H)-furanone (sotolone) from 4- hydroxy-l-isoleucine (1) and the corresponding lactone 3-amino-4, 5-dimethyl-3, 4-dihydro-2 (5 H)-furanone (2) by thermally induced oxidative deamination was corroborated. The formation of sotolone was studied in model systems by reacting 1 or 2 with different carbonyl compounds in a phosphate buffer at pH 5 at 100° C for 1 h. The amount of sotolone was ...
