l-Ribose was synthesized in a concise manner from d-mannono-1, 4-lactone using one-pot inversion conditions. Treatment of d-mannono-1, 4-lactone with piperidine, followed by mesylation-induced SN2-type O-alkylation, afforded the desired one-pot inversion in an optimum yield, and the following straightforward transformations provided l-ribose in good yields.
![[6-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl] benzoate Structure](https://image.chemsrc.com/caspic/256/403604-98-8.png)
