A practical one-pot synthesis of 5-aryl-2-furaldehydes

…, F Roschangar, SJ Hodson, A Millar, MH Osterhout

Index: McClure; Roschangar; Hodson; Millar; Osterhout Synthesis, 2001 , # 11 p. 1681 - 1685

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Citation Number: 26

Abstract

Abstract A useful one-pot synthesis of 5-aryl-2-furaldehydes via palladium-mediated Suzuki coupling of aryl halides with in situ generated 5-(diethoxymethyl)-2-furylboronic acid is described. The procedure has general applicability, delivers high yields, and is amenable to scale-up.

~90%

~64%

~85%

~78%

~78%

~87%

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A practical one-pot synthesis of 5-aryl-2-furaldehydes

[Synthesis, , # 11 p. 1681 - 1685]