Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Novel tri-substituted 1,2,4-triazoles are synthesized via complementary, regiospecific routes as part of a lead finding exercise. A key feature of one of the syntheses is recognition of an intrinsic regioselectivity toward deprotonation in the 1-phenylguanazole substrate.