The echinocandins are a well-known class of lipopeptides characterized by their potent antifungal activity against Candida species. The mechanism of action of the echinocandina is generally thought to be the inhibition of &1, 3-glucan synthesis, an important structural component in the cell wall of Candida species. Extensive structureactivity studies on the fatty acid side chain of echinocandin B (1) led to the preparation of the clinical candidate ...
