Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides

…, R Houssin, JP Hénichart, P Colson, C Houssier…

Index: Dudouit, Fabienne; Goossens, Jean-Francois; Houssin, Raymond; Henichart, Jean-Pierre; Colson, Pierre; Houssier, Claude; Gelus, Nathalie; Bailly, Christian Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 553 - 557

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Citation Number: 13

Abstract

Three 4-arylcarboxamidopyrrolo-2-carboxyanilides bearing different substituents on the pyrrole nitrogen were synthesized and evaluated for their capacities to bind to specific sequences within the minor groove of DNA and to inhibit human topoisomerases I and II in ...