Tetrahedron Letters

α-(Trifluoromethyl) ethenyl boronic acid as a useful trifluoromethyl containing building block. Preparation and palladium-catalysed coupling with aryl halides

B Jiang, QF Wang, CG Yang, M Xu

Index: Jiang, Biao; Wang, Quan-Fu; Yang, Cai-Guang; Xu, Min Tetrahedron Letters, 2001 , vol. 42, # 24 p. 4083 - 4085

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Citation Number: 41

Abstract

α-(Trifluoromethyl) ethenyl boronic acid was conveniently prepared from the reaction of readily available 2-bromotrifluoropropene with alkyl borate and magnesium in one-pot. This boronic acid can undergo palladium-catalysed coupling reactions with aryl halides to afford a series of useful α-(trifluoromethyl) styrene derivatives in high yield.