α-1, 4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

P Simerska, MP Christie, D Goodwin, FEC Jen…

Index: Simerska, Pavla; Christie, Michelle P.; Goodwin, Daryn; Jen, Freda E.-C.; Jennings, Michael P.; Toth, Istvan Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 196 - 202

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Citation Number: 4

Abstract

Abstract Glycosylation of therapeutic peptides has been reported to improve delivery and targeting of various vaccines and drugs to specific cells/tissues. However, chemical synthesis of complex oligosaccharide derivatives via conventional methods can be challenging due to the need for several orthogonal hydroxyl group protections. Liposaccharyl galactosyltransferase C, a naturally occurring glycosyltransferase enzyme ...