Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D2/3 receptors in their high-affinity …

…, V Shalgunov, HM Janssen, PM Fransen…

Index: Van Wieringen, Jan-Peter; Shalgunov, Vladimir; Janssen, Henk M.; Fransen, P. Michel; Janssen, Anton G. M.; Michel, Martin C.; Booij, Jan; Elsinga, Philip H. Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 391 - 410

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Citation Number: 8

Abstract

Imaging of dopamine D2/3 receptors (D2/3R) can shed light on the nature of several neuropsychiatric disorders in which dysregulation of D2/3R signaling is involved. Agonist D2/3 tracers for PET/SPECT imaging are considered to be superior to antagonists because they are more sensitive to dopamine concentrations and may selectively label the high- affinity receptor state. Carbon-11-labeled D2/3R agonists have been developed, but these ...