Enzymatic preparation of both L-and D-enantiomers of phosphonic and phosphonous analogues of alanine using penicillin acylase

VA Solodenko, MY Belik, SV Galushko, VP Kukhar…

Index: Solodenko, Vladimir A.; Belik, Michail Y.; Galushko, Sergei V.; Kukhar, Valeri P.; Kozlova, Elena V.; et al. Tetrahedron: Asymmetry, 1993 , vol. 4, # 9 p. 1965 - 1968

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Citation Number: 42

Abstract

Abstract D-Enantiomers of N-acylated 1-aminoethylphosphonic and 1- aminoethylphosphonous acids were able to be hydrolyzed with high concentrations of penicillin acylase in a reasonable time period. This finding was used to prepare both L-and D-enantiomers of these phosphorus analogues of alanine by stepwise enzymatic hydrolysis of their racemic N-phenylacetyl derivatives using the same enzyme-penicillin acylase-by ...