Urea-, thiourea-, and guanidine-linked glycooligomers as phosphate binders in water

…, C Ortiz Mellet, JM García Fernández

Index: Blanco, Jose L. Jimenez; Bootello, Purificacion; Mellet, Carmen Ortiz; Gallego, Ricardo Gutierrez; Fernandez, Jose M. Garcia Chemical Communications (Cambridge, United Kingdom), 2004 , # 1 p. 92 - 93

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Citation Number: 76

Abstract

β-(1→ 6)-Linked pseudodi-and pseudotrisaccharides incorporating alternating pseudoamide-type (urea, thiourea, guanidine) intersaccharide bridges have been prepared and evaluated as phosphate binders in water. The monosaccharide subunits induce the Z, Z rotameric form at the pseudoamide segments, thus favoring their participation in bidentate hydrogen-bond interactions with oxoanions. Moreover, the conformational properties ...