Synthesis of 3-aminomethyl-substituted pyrazoles and isoxazoles

DM Musatov, EV Starodubtseva, AK Rakishev…

Index: Musatov; Starodubtseva; Rakishev; Turova; Vinogradov Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1199 - 1203

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Abstract

Abstract A series of new 3-(aminomethyl) pyrazoles and 3-(aminomethyl) isoxazoles was synthesized along a route involving the formation as key intermediates of esters of 5- substituted 1 H-pyrazole-3-carboxylic and 1 H-isoxazole-3-carboxylic acids. All compounds obtained were characterized by physicochemical constants, IR, 1 H, 13 C NMR, and mass spectra.