Nonquaternary cholinesterase reactivators. 2.. alpha.-Heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase …

RA Kenley, CD Bedford, OD Dailey Jr…

Index: Kenley; Bedford; Dailey Jr.; Howd; Miller Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1201 - 1211

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Citation Number: 29

Abstract

We prepared six pairs of a-heteroaromatic aldoximes, RC (= NOH) H, and thiohydroximates, RC (= NOH) S-(CH2) 2N (C2Hs) 2, where R represents various oxadiazole and thiadiazole rings. Each compound was characterized with respect to the following: structure,( hydroxyimino) methyl acid dissociation constant, nucleophilicity toward trigonal carbon and tetrahedral phosphorus, octanol-buffer partition coefficient, reversible inhibition of eel ...